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This is a summary of the most important information about Invega (Paliperidone). For details, talk to your doctor, pharmacist, physician, or other healthcare professional.

What is Invega (Paliperidone)?

Invega extended- release tablets are used to treat schizophrenia. Paliperidone is an atypical antipsychotic medicine.

Who should not use Invega?

You should not take Invega if you are allergic to paliperidone, risperidone or to any of the ingredients in this medication.

What are the risks?

The following are the major potential risks and side effects of Invega (Paliperidone) therapy. However, this list is not complete.

  • Increased chance of death and strokes in elderly patients with dementia. Elderly patients with dementia who are treated with atypical antipsychotics, such as Invega, have a higher chance for death than patients who do not take these medicines. Paliperidone (Invega) is not approved to treat dementia.
  • Neuroleptic malignant syndrome (NMS), a life-threatening nervous system problem. NMS can cause a high fever, stiff muscles, sweating, a fast or irregular heart beat, change in blood pressure, and confusion. NMS can affect your kidneys. NMS is a medical emergency. Get medical help right away if you have these symptoms.
  • QT prolongation (a serious heart problem). Talk to your doctor or pharmacist if you have or had any heart problems.
  • Tardive dyskinesia (TD), a movement problem. Uncontrollable, slow or jerky facial or body movements that may not go away. Call your healthcare professional right away if you get muscle movements that cannot be stopped.
  • Dizziness and fainting, caused by a drop in blood pressure may happen with Invega, especially when you first start taking this medicine or when the dose is increased. Get up slowly when sitting or lying down.
  • High blood sugar and diabetes. These side effects may even lead to death in some patients. Patients with diabetes or those who have a higher chance for diabetes should have their blood sugar checked often.
  • Impaired judgment, thinking, or motor skills. You should be careful when driving or using machines until you know how Invega affects you.
  • Other serious side effects may include: seizures, trouble swallowing, suicide, an erection that does not go away, and fever and bruising (thrombotic thrombocytopenic purpura).
  • Overheating and dehydration. Invega may make you more sensitive to heat. You may have trouble cooling off, or be more likely to become dehydrated. Be careful when exercising or doing activities in the heat.
  • Some common side effects with Invega include: involuntary movements, restlessness, tremors and muscle stiffness, headache, fast heart beat, sleepiness, dizziness, anxiety, upset stomach and nausea.

    What should I tell my healthcare professional?

    Before you start taking Invega (Paliperidone), tell your doctor, pharmacist, or other healthcare professional if you:

  • have or have had seizures
  • have or had heart problems
  • have or had diabetes or increased blood sugar
  • have or had problems with your esophagus, stomach or small or large intestine
  • have or had liver disease
  • drink alcohol
  • are pregnant, trying to become pregnant, or are breast-feeding.

    Paliperidone (Invega) has not been studied in children under 18 years of age.

    Can other medicines or food affect Invega (Paliperidone)?

    Invega and certain other medicines can interact with each other. Tell your physician or pharmacist about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Paliperidone may affect how your other medicines work. Know the medicines you take. Keep a list of them with you to show your healthcare professional.

    Especially tell your physician or healthcare professional if you take:

  • blood pressure medicines
  • levodopa and medicines called dopamine agonists

    Avoid drinking alcohol while taking this medication.

    How should I take Invega (Paliperidone)?

  • Take Invega once a day in the morning.
  • Swallow Paliperidone (Invega) tablets whole with water or other liquid. Do not chew, divide, or crush Invega tablets.
  • The tablet shell will pass though your body and you may see it in your stool.
  • Invega can be taken with or without food.

    Paliperidone (Invega) related pharmaceutical drugs and medications

    Trade name of the drug Pharmaceutical forms and doses Companies
  • N / A
  • N / A
  • Haloperidol Abraxis
  • Injectable; Injection; Haloperidol Lactate 5 mg / ml
  • Abraxis BioScience

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